HbA1c measurement

Targeting HbA1c: standardization and clinical laboratory measurement.

In this article, we have provided a review of the implications of diabetes and HbA1c, the standardization efforts of HbAlc as a long-term monitor of average glycemia, the pathobiology of HbA1c, as well as current measurement pitfalls associated with clinical-laboratory measurements. Long-term studies, including the DCCT and UKPDS, have established a correlation between average blood glucose (Hb...

HbG-Coushatta: an unexpected discovery during HbA1c measurement.

BACKGROUND Hemoglobin (Hb) A1c is widely used as the gold standard for blood glucose level monitoring in diabetic patients. Various methods are being used in clinical laboratories for HbA1c measurement. However, the presence of Hb variants may interfere with HbA1c measurement. METHODS The HbA1c assay was performed routinely in a 55-year old woman with type 2 diabetes and hyperlipidemia that w...

Comparison of Three Methods for Measurement of HbA1c

Aim: To compare three methods for measurement of blood HbA1c as to reliability, ease and time consumption.” Method: Measurements of HbA1c were made in blood from 120 patients with pre-diabetes and diabetes using a turbidimetric inhibition immunoassay (TINIA), which also required measurement of total hemoglobin, a particle-enhanced immunoturbidimetric assay (PEITT) without measurement of total h...

Effect of HbE heterozygosity on the measurement of HbA1c.

AIM Measurement of HbA1c provides an excellent measure of glycaemic control for diabetic patients. However, haemoglobin (Hb) variants are known to interfere with HbA1c analysis. In our laboratory HbA1c measurement is performed by Variant II turbo 2.0. The aim of this study is to investigate the influence of HbE trait on HbA1c analysis. METHODS Haemoglobin variants were identified by HbA1c ana...

Evaluation of four POCT-Systems for the measurement of HbA1c